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The results, published in the Hepatology journal have important implications in the treatment of obesity and other related diseases such as diabetes, insulin resistance and non-alcoholic liver disease fatty liver, according to the Dr. Jeffrey Browning, assistant professor in the imagery and inner medicine at UT Southwestern.
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"Instead of thinking about drugs against obesity and diseases, improved nutrition might be not only manage and treat these diseases, but also prevent them," said Dr. Browning.
The study did not analyze the effectiveness of both systems. However, the average weight loss for those who followed a low-carb diet was 4.3 kg for two weeks, while those who followed a low calorie diet lost an average of 2.3 pounds.
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Glucose, a form of sugar, and fat are both sources of energy, metabolized in the liver and used as energy in the body. To determine the influence of consumption on the production and use of glucose in the liver, the study involved 14 adults overweight or obese, randomly assigned to either low-carb diet is low in calories, and seven lean adults who had normal consumption.
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After two weeks, researchers have used imaging techniques to analyze the methods used by each person to make glucose. "We found huge differences in the location and how the liver was producing glucose, depending on the consumption of the person," said Dr. Browning.
The people who followed a low-carbohydrate diet produced more glucose from lactate and amino acids than those who followed a low calorie diet. "The more we understand how the liver produces glucose, the more we can control metabolic disorders with changes in consumption."
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In addition, those who followed a low calorie diet produced about 40% of the glucose to glycerol, which comes from carbohydrates stored in the liver until the body needs it. In contrast, those who followed a low-carb diet, only got 20% of their glucose glycerin - on the contrary, they burned the fat through the liver for energy.
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The results are important because the accumulation of excess fat in the liver may cause disease NAFLD. This is the most common liver crises in Western countries illness and is associated with metabolic disorders such as insulin resistance, diabetes and obesity, and can cause liver inflammation, cirrhosis and liver cancer.
"Energy production is expensive for the liver," says Dr. Browning. "It seems that for those who follow a low-carb diet, the liver is forced to burn excess fat in order to meet this expense."
Dr. Browning adds that his future studies will focus on changes in liver metabolism due to a restriction of carbohydrates, and if they can help people affected by the disease of NAFLD. A link has been established between the consumption of carbohydrates and disease.
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